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Selegiline

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Eldepryl®;Emsam®;Zelapar®
    • Brand Names: Canada: Apo-Selegiline®;Gen-Selegiline;Mylan-Selegiline;Novo-Selegiline;Nu-Selegiline
    • Mexican Brand Names: Niar
    • Pharmacologic Category: Anti-Parkinson's Agent, MAO Type B Inhibitor;Antidepressant, Monoamine Oxidase Inhibitor

    Uses
    • It is used to treat Parkinson's disease.
    • It is used to treat low mood (depression).
    • Selegiline helps keep chemical balance in the brain.
    • With low mood (depression), sleep and eating habits may get better fast. Other signs may take up to 4 to 6 weeks to get better.

    Dosing

    How to take

    • All products:
    • Use this drug early in the day to stop sleep problems.
    • Follow a diet plan. Some foods and drinks taken with higher doses of this drug may cause very risky effects such as sudden high blood pressure. To avoid these problems, get a list of foods to avoid.
    • Keep a diary of your signs.
    • Tablets and capsules:
    • Take this drug with food.
    • Oral-disintegrating tablet:
    • Place on your tongue and let it melt. Water is not needed. Do not swallow it whole. Do not chew, break, or crush it.
    • Do not eat or drink for at least 5 minutes after taking this drug.
    • Skin patch:
    • Wash your hands before and after use.
    • Put patch on clean, dry, healthy skin on the chest, back, upper leg, or upper arm.
    • Move the patch site with each patch.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not use 2 doses or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect capsules and tablets from water. Do not store in a bathroom or kitchen.
    • Use oral disintegrating tablets within 3 months of opening pouch.

    Safety



    Warnings

    • The want to harm yourself is an unsafe sign of low mood (depression). It may last until your low mood is fully treated. If you are planning on harming yourself, call the ER (emergency department) right away.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.
    • Please read the medication guide.

    Avoid

    • If you have an allergy to selegiline or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
    • Skin patch:
    • If you have pheochromocytoma.
    • Stop fluoxetine for at least 5 weeks before starting this drug.

    Precautions

    • If you have been taking this drug for many weeks, talk with your doctor before stopping. You may want to slowly stop this drug.
    • If you are taking a high dose (more than 10 mg per day of the capsule or tablet, more than 2.5 mg per day of the oral disintegrating tablet, or more than 6 mg per day of the skin patch) of this drug, avoid aged meats and cheeses, soy sauce, some types of beans, sauerkraut, beer, yeast extracts, and others. Talk with your doctor.
    • If you have PKU, talk with your doctor. Some products have phenylalanine.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • If you are taking this drug and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
    • Avoid beer, wine, or mixed drinks.
    • You may not be alert. Avoid driving and doing other tasks or actions until you see how this drug affects you.
    • Take good care of your teeth. See a dentist often.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.
    • Skin patch:
    • Avoid products that have caffeine, phenylalanine, St John's wort, tryptophan, or tyrosine.
    • Avoid use of heat sources (such as sunlamps, tanning beds, heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds). Avoid long, hot baths or sunbathing. Your temperature may rise and cause too much drug to be let go all at once.

    Side Effects

    • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Not able to sleep.
    • Skin irritation.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • If you are planning to harm yourself or the want to harm yourself gets worse.
    • A fast heartbeat.
    • Very bad dizziness or passing out.
    • Change in thinking clearly and with logic.
    • Big change in balance.
    • Strong urges that are hard to control (such as gambling or sex).
    • Very nervous and excitable.
    • Very bad flushing.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Very bad skin irritation.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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