Table of Contents > Drug > Aprepitant Print

Aprepitant

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • U.S. Brand Names: Emend®
    • Canadian Brand Names: Emend®
    • Mexican Brand Names: Emend
    • Pharmacologic Category: Antiemetic;Substance P/Neurokinin 1 Receptor Antagonist

    Uses
    • This medicine is used to prevent nausea and vomiting.
    • Aprepitant blocks chemicals in the stomach and brain that cause nausea and vomiting.

    Dosing

    How to take

    • To prevent nausea from chemotherapy, take first dose 1 hour before treatment or procedure.
    • To prevent nausea from surgery, take this medicine 3 hours before surgery.
    • Take this medicine with or without food. Take with food if it causes an upset stomach.

    Missed Dose

    • Take a missed dose as soon as possible.
    • If it is almost time for the next dose, skip the missed dose and return to your regular schedule.
    • Do not take a double dose or extra doses.

    Storage

    • Store at room temperature.
    • Protect from moisture. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.

    Avoid

    • If you have an allergy to aprepitant or any other part of this medicine.
    • Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

    Precautions

    • If you have liver disease, talk with healthcare provider.
    • Check medicines with healthcare provider. This medicine may not mix well with other medicines.
    • Do not take St John's wort with this medicine. It may make this medicine less effective.
    • Avoid grapefruit and grapefruit juice.
    • Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.
    • Tell healthcare provider if you are pregnant or plan on getting pregnant.
    • Tell healthcare provider if you are breast-feeding.

    Side Effects

    • Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.
    • Feeling tired or weak.
    • Diarrhea.
    • Constipation. More liquids, regular exercise, or a fiber-containing diet may help. Talk with healthcare provider about a stool softener or laxative.
    • Not hungry.
    • Hiccups.

    Monitoring

    • Change in condition being treated. Is it better, worse, or about the same?
    • Follow up with healthcare provider.

    Contact a healthcare provider

    • If you suspect an overdose, call your local poison control center or emergency department immediately.
    • Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
    • Significant change in thinking clearly and logically.
    • Severe nausea or vomiting.
    • Feeling extremely tired or weak.
    • Any rash.
    • No improvement in condition or feeling worse.

    General Statements

    • If you have a life-threatening allergy, wear allergy identification at all times.
    • Do not share your medicine with others and do not take anyone else's medicine.
    • Keep all medicine out of the reach of children and pets.
    • Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
    • Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).
    • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
    • Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.


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